In this 1-Minute video, Dr. Carol Shields offers advice for treating iris melanoma. Ocular oncologists generally devise treatment strategies based on tumor size, location and shedding of pigment. Small tumors are typically resected, while large tumors might be treated with radiotherapy. But enucleation may be necessary for tumors that have shed pigment. Tube shunts and minimally invasive glaucoma surgery (MIGS) should be avoided in patients with unilateral glaucoma and an iris pigmented lesion; physicians should refer the patient to an ocular oncologist to rule out melanoma.